Ibritumomab tiuxetan
Zevalin (ibritumomab tiuxetan) is an antibody drug conjugate pharmaceutical. Ibritumomab tiuxetan was first approved as Zevalin on 2002-02-19. It is used to treat b-cell lymphoma and follicular lymphoma in the USA. It has been approved in Europe to treat follicular lymphoma. The pharmaceutical is active against B-lymphocyte antigen CD20.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Zevalin
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| zevalin | Biologic Licensing Application | 2023-04-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| b-cell lymphoma | — | D016393 | — |
| follicular lymphoma | — | D008224 | C82 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
ibritumomab tiuxetan, Zevalin, Acrotech Biopharma Inc. | |||
| 2109-02-19 | Orphan excl. | ||
Patent Expiration
No data
Clinical
Clinical Trials
107 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 6 | 19 | 6 | 1 | 6 | 35 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 3 | 14 | 3 | — | — | 18 |
| Follicular lymphoma | D008224 | — | C82 | 3 | 10 | 5 | — | 1 | 17 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 11 | 26 | — | — | 3 | 34 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 2 | 9 | — | — | — | 10 |
| Waldenstrom macroglobulinemia | D008258 | HP_0005508 | C88.0 | 4 | 5 | — | — | — | 6 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 3 | 3 | — | — | 1 | 5 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 3 | 4 | — | — | — | 5 |
| B-cell lymphoma | D016393 | — | — | 2 | 3 | — | — | — | 4 |
| Leukemia | D007938 | — | C95 | 1 | 3 | — | — | — | 3 |
| Burkitt lymphoma | D002051 | — | C83.7 | 1 | 3 | — | — | — | 3 |
| Multiple myeloma | D009101 | — | C90.0 | — | 1 | — | — | 1 | 2 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Plasma cell neoplasms | D054219 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ibritumomab tiuxetan |
| INN | ibritumomab tiuxetan |
| Description | Immunoglobulin G1, anti-(human CD20 (antigen)) (mouse monoclonal IDECÂY2B8 71-chain), disulfide with mouse monoclonal IDEC-Y2B8 x-chain, dimer, iV-[2-[bis(carboxymethyl)amino]-3-(4-isothiocyanatophenyl) propyl]ÂiV-[2-[bis(carboxymethyl) amino]propyl]glycine conjugate |
| Classification | Antibody |
| Drug class | monoclonal antibodies; chelating agents |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 206181-63-7 |
| RxCUI | 262323 |
| ChEMBL ID | CHEMBL1201606 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00078 |
| UNII ID | 4Q52C550XK (ChemIDplus, GSRS) |
Target
Agency Approved
MS4A1
MS4A1
Organism
Homo sapiens
Gene name
MS4A1
Gene synonyms
CD20
NCBI Gene ID
Protein name
B-lymphocyte antigen CD20
Protein synonyms
B-lymphocyte cell-surface antigen B1, B-lymphocyte surface antigen B1, Bp35, CD20, CD20 antigen, CD20 receptor, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, membrane-spanning 4-domains, subfamily A, member 1
Uniprot ID
Mouse ortholog
Ms4a1 (12482)
B-lymphocyte antigen CD20 (P19437)
Alternate
No data
Variants
No data
Financial
Revenue by drug
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Zevalin – Spectrum Pharmaceuticals
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,498 documents
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Safety
Black-box Warning
Black-box warning for: Zevalin
Adverse Events
Top Adverse Reactions
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1,912 adverse events reported
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